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In one study, only 50% of children with cri du chat syndrome were able to feed themselves with a spoon by 3.5 years of age.

A variety of additional findings may occur in association with cri du chat syndrome.

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NORD gratefully acknowledges Scott Pentiuk MD, Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, and Adam Mezoff, MD, Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, for assistance in the preparation of this report.

Summary Cri du chat syndrome (Cd CS or 5p-) is a rare genetic disorder in which a variable portion of the short arm of chromosome 5 is missing or deleted (monosomic).

Symptoms vary greatly from case to case depending upon the exact size and location of the deleted genetic material.

Common symptoms include a distinctive cry that resembles the mewing of a cat, characteristic facial features, slow growth, and microcephaly, a condition that indicates that head circumference is smaller than would be expected for an infant's age and sex.

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Additional symptoms affecting different organ systems of the body can also occur.Some children may display hyperactivity or self-abusive behaviors.While children with cri du chat syndrome are born hypotonic (low muscle tone), they tend to become hypertonic (high muscle tone) as they grow older.Most cases are thought arise from spontaneous (de novo) genetic errors very early in embryonic development.Introduction The disorder was first described in the medical literature in 1963 by doctor Lejeune who named the disorder after the distinctive cat-like cry.Improper alignment of the upper and lower teeth (malocclusion) may also occur.